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A single skin administration of a PSR-MNs patch (2 cm 2 cm) which contains 4 programmable core-shell MNs patches (1 cm 2 each, so-called pixels) enables the repeated release of Semaglutide every 7 days and sustains the drug efficacy for an unprecedented one-month period, simulating the effect of using four bolus injections spaced 7 days apart

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