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In addition, some aspects of GLP-1 beyond weight loss, such as preclinical evidence on GLP-1 effects in directly modulating the hypothalamuspituitarygonadal axis, or the effects of GLP-1RA on clinical and biochemical expression of hyperandrogenism, still deserve a greater insight, especially in light of a possible therapeutic use in PCOS women independently of obesity

As we await prospective data, clinical practice should consider the difference between abrupt stop vs gradual taper when counseling patients about expectations after therapy

Design Population based cohort study using a prevalent new-user design, emulating a trial

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The prevalence of obesity continues to rise, but one class of drugsGLP-1 receptor agonistsis getting attention for its potential as an effective treatment...

Process differences introduced by follow-on manufacturers may result in changes in quality and clinical outcomes