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We have not observed concerning signs of muscle weakness in clinical trials to date." The company said 11.3 percent of patients on the highest dose during retatrutide's clinical trial stopped taking the drug during the study because of significant side effects: nausea, diarrhea, constipation, vomiting and upper respiratory tract infection

But if you lose less strength or fitness in proportion to your overall weight loss, youll still end up with greater functional fitness: youll have an easier time getting up from a chair, be able to walk for longer, and so on

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Summary and Future Perspectives The recent comparative studies underscore Tirzepatide's superior efficacy in weight loss and glycemic control compared to Semaglutide

September 2018

Therefore, while the blood pressurelowering effects seen with GLP-1 therapy are not dramatic, they are biologically consistent and clinically meaningful when considered as part of a broader cardiometabolic strategy