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[13] Important limitations in the current evidence base include: Most studies measure acute GLP-1 responses to single meals rather than long-term effects Sample sizes are often small, and study populations vary widely The magnitude of GLP-1 increase from dietary interventions is substantially smaller than that achieved with pharmaceutical GLP-1 agonists Individual responses vary considerably based on genetics, baseline metabolic health, and gut microbiome composition From a safety perspective , natural approaches to supporting GLP-1 production through whole foods and lifestyle modifications are generally considered safe for most individuals

Application of GLP-1R agonists in AD Several studies have reported that GLP-1 agonists could protect brain against various damage in AD models ( Supplementary Table 1 and Table 1 )

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[DOI] [PubMed] [Google Scholar] 28.Cho Y.M., Fujita Y., Kieffer T.J

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The cardiovascular advantages of GLP-1 receptor agonists go beyond blood sugar management