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Risk factors include renal impairment, hepatic dysfunction, excessive alcohol use, and conditions causing tissue hypoxia

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Hypertension in diabetes care: emerging roles of recent hypoglycemic agents

Clinical trial data show that while fat mass accounts for the majority of weight loss, some lean mass reduction also occurs, which could potentially affect muscle function

It is therefore plausible that direct interaction of cholesterol molecules with specific binding pockets in the GLP-1R might at least be partially responsible for cholesterol modulation of GLP-1R function

doi: 10.1097/WCO.0000000000000634