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As an example, the results of a meta-analysis evaluating the risk of cardiorenal effects exerted by GLP-1RAs and SGLT2is evidenced similar benefits (about 1214% risk reduction), although GLP-1RAs are superior for stroke risk reduction [142]

[DOI] [PubMed] [Google Scholar] 114.Laser B., Meda P., Constant I., Philippe J

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Patients should never discontinue or adjust medications without provider guidance, as abrupt changes can lead to worsening or uncontrolled blood pressure or loss of glycemic control

Limitations of the approach Our meta-analysis and systematic review has limitations that should be considered when interpreting our findings

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