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Science (1993) 259(5091):8791.10.1126/science.7678183 11 ClavelTDesmarchelierCHallerDGrardPRohnSLepagePet alIntestinal microbiota in metabolic diseases: from bacterial community structure and functions to species of pathophysiological relevance

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GLP-1 agonists benefit MASH patients by reducing liver fat, decreasing inflammation, and hence improving liver tissue structure, potentially slowing the progression of the disease

Another may be proof that other treatments were tried first

Possible fixed drug combinations are under investigation: Semaglutide + Amylin analog (enhanced appetite suppression) Semaglutide + GIP/GLP-1 dual agonist (complementary metabolic effects) Semaglutide + SGLT2 inhibitor (cardiometabolic additive effect) 1