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Severe or recurrent genital mycotic infections and urinary tract infections warrant treatment suspension if they become problematic ( Canagliflozin specifically should be discontinued in patients with a heightened risk of amputations, including those with a history of amputations, severe peripheral neuropathy, severe peripheral arterial disease, or active lower-limb ulcers or infections, as well as in individuals with an increased fracture risk, particularly those with previous osteoporotic fractures ( 3.3 Mechanism of action of GLP1 receptor agonists GLP-1 is a hormone belonging to the incretins that is produced in the gastrointestinal tract, by L cells, in response to the intake of nutrients, especially fat and glucose ( GLP-1 RAs like liraglutide and semaglutide, offer a therapeutic advantage over native GLP-1 by being resistant to degradation by dipeptidyl peptidase-4 (DPP-4)

On the day after expiration, the medication is probably very similar to how it was the day before

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Gli autori concludono che entrambi i farmaci, quando associati ad altri trattamenti antidiabetici, riducono lincidenza di infarto miocardico non fatale e di ipoglicemie severe, prevengono lo sviluppo di CKD e abbassano la mortalit in misura proporzionale al profilo di rischio cardiovascolare e renale del paziente al basale ( very low, low, moderate, high, e very high )