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Plaintiffs in thousands of lawsuits now pending in federal and state courts allege that the manufacturers of these drugs failed to adequately warn patients and physicians about these severe risks

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By contrast, peptides such as PYY and apelin were discontinued primarily due to formulation limitations or tolerability at supraphysiologic dosespharmacologic rather than biological failuresand therefore meet criteria for re-evaluation

However, as Ozempic use rises globally, so are the reports of severe complications from GLP-1s, including gastroparesis and pancreatitis