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[174] reported minimal or no hormonal effects from other antidiabetic agents

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A 2025 retrospective cohort study published in the Journal of Diabetes Complications found that tirzepatide was associated with a significantly reduced risk of ED compared to three other diabetes medications

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Retatrutide Side Effects In clinical trials, the most common side effects observed in patients treated with these medications were nausea, low blood sugar, diarrhea, constipation, vomiting, headache, decreased appetite, upset stomach, fatigue, dizziness, and abdominal pain