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Expect gradual appetite reduction and possible mild digestive symptoms initially

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In men with obesity-related functional hypogonadism, excess fat tissue can increase aromatase activity, converting more testosterone into estradiol, while inflammation and insulin resistance further suppress the HPG axis

15 febbraio 2022 [citato 30 giugno 2024];19(2):e1003901

Delayed gastric emptying may affect the absorption of some oral medicines, particularly those with a narrow therapeutic index (for example, levothyroxine or certain anticoagulants), and may reduce overall nutritional intake during active weight loss

Some report that their periods have become lighter and less painful, while others have noticed delayed cycles, spotting, or even more intense cramps during the initial adjustment phase