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This strategy was based on previous structural data showing that position 5 of the FFAT core motif is located within a hydrophobic pocket in the MSP domain of VAP 41 , with previous studies indicating that introducing a negative charge in this position causes a steric hindrance which effectively disrupts FFAT motifVAP interaction 42

GLP-1R activation participates in CICR by sensitizing the intracellular Ca 2+ channels (IP 3 R and RYR) to the stimulatory effects of Ca 2+

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Master Meal Timing Eat small, balanced meals every 3-4 hours, or if intermittent fasting, have 2 main meals with a high-protein snack in between