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The SUMMIT trial, conducted by Eli Lilly and published in November 2024, focused on 731 patients with both heart failure (ejection fraction 50%) and obesity

Hypoglycaemia concerns: Although uncommon with Mounjaro monotherapy, patients using the medication alongside other glucose-lowering agents (particularly insulin or sulphonylureas) may experience nocturnal hypoglycaemia, which can cause night-time awakening, sweating, and disrupted sleep architecture

The mechanistic case for combining HRT and GLP-1 receptor agonists in menopausal women is strong

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The turning point appears to happen around the two-month mark