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It must be acknowledged that despite similar point estimate of the HRs and the absence of statistically significant heterogeneity, SGLT2i in combination with GLP1Ra displayed HR with confidence intervals below 1.0 for chronic kidney disease progression, but not for hospitalization for heart failure or cardiovascular death

53 In both Phase 1a and 1b trials, it has been established that orforglipron does not have food or water administration restrictions and may provide a safe and effective oral treatment option for patients with T2D and other indications

JAMA 282(18): 173744

Nausea, vomiting, diarrhea, constipation, and abdominal pain were mainly transient and mild to moderate in severity

Wegovy and Ozempic can promote weight loss of up to 12-14% of body weight

With these points in mind, we undertook a broad assessment of published clinical data, curating the body weight loss (% from baseline), glycosylated hemoglobin levels (HbA1c), and nausea responses (% patients reporting) from the SUSTAIN 3, SUSTAIN 7, SCALE Diabetes, SURPASS 2, and STEP 2 trials (64, 66, 67) ( Figures 1AC )