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Healthcare professionals should maintain a low threshold for investigating potential biliary pathology in patients on GLP-1 agonists who present with compatible symptoms

Verdict at a Glance Pemvidutide and survodutide are both GLP-1/glucagon dual agonists being developed for obesity and MASH, but survodutide is further ahead in clinical development with more advanced Phase 3 programs, higher-tier regulatory designations (Breakthrough Therapy vs Fast Track), and greater weight loss in Phase 2 (18.7% vs 15.6%)

By boosting the expression of osteoclastogenic indicators following GLP-1R knockdown, the authors established that GLP-1R might be relevant for osteoclastogenesis and validated the presence of GLP-1R on BMMs and RAW264.7 cells

GLP-1 medications slow gastric emptying and reduce appetite, which typically lowers overall food intake

95% CI [0.410.95]

Addressing GLP-1 Emotional Eating : Breaking the Comfort Cycle Emotional eating-the habit of turning to food for comfort, stress relief, or to cope with boredom-is a major hurdle in weight loss