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Metformin may also cause side effects including diarrhea, nausea, and vomiting

Because SIBO testing is uncommon in the general population, increased testing among GLP-1 users can make it appear that cases are rising, when in reality we are simply increasing testing and therefore finding more cases

Notably, GLP-1RAs slow the transit time of the gastrointestinal (GI) tract and suppress appetite, which could displace nutrient intake and result in mineral and vitamin deficiencies

Varied sample size (p = 0.026), optimistic conclusions (p = 0.002), and comparisons between GLP-1RA and placebo (p = 0.000) were significantly correlated with HbA1c change