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Discussion In this population-based, propensity-weighted cohort study, we found no evidence of an association between GLP-1RA and increased risk for SIS when compared with SGLT-2i, when prescribed to treat type 2 diabetes in patients with concomitant obesity

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Functional MRI studies have shown that people on GLP-1 therapy show reduced activation in brain reward centers when viewing food images

GLP-1 receptor agonists intentionally slow gastric emptying to promote satiety and reduce blood glucose spikesbut this mechanism poses a significant safety concern for patients with existing gastroparesis

If it sounds too good to be true, it probably is." Supriya Rao, MD, Obesity Physician For those seeking other cost-saving options, cash-pay programs may provide another solution