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Emerging and Combination Therapies The success of dual agonism has spurred the development of even more advanced combination therapies targeting multiple metabolic pathways

However, compared to semaglutide, it more intensely activates brain regions that regulate reward, such as the limbic system

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Using both SGLT-2 and DPP-4 inhibitors as active comparators strengthened study validity, while register linkage minimized selection and recall bias by ensuring exposures were recorded independently of outcomes

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