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We and others have shown that GLP-1 drugs reduce risks of many substance use and addiction disorders.

As we await prospective data, clinical practice should consider the difference between abrupt stop vs gradual taper when counseling patients about expectations after therapy

Combined findings revealed that the risk of depression was linked to the utilization of GLP-1RA (OR=1.49, 95% CI: 1.181.88)

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However, sudden visual loss, a new blind area or rapidly worsening eyesight requires emergency evaluation