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Like virtually all medications, incretin mimetics come with side-effects, leading some patients to abandon treatment

Who Should Stay on GLP-1 Compounds Long-Term: Safety and Clinical Considerations GLP-1 compounds are indicated for patients with obesity or overweight with comorbidities

Zepbound (tirzepatide) is a dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 receptor agonist-the first and only approved treatment activating both incretin hormone receptors

The drugs slow the muscular contractions that move food through the digestive system, reduce stomach acid secretion, and alter the signals sent between the gut and brain

This is particularly beneficial for those with insulin resistance, a common issue in type 2 diabetes

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