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Semaglutide is contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, though the relevance to humans remains uncertain

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doi: 10.3389/fendo.2023.1136796

For practical purposes, what this means is that your compounded semaglutide is in a constant, slow process of breaking down from the moment it is formulated

doi:10.1177/2047487320939674 4

It tells us that yes, the concern about muscle loss is real and deserves attention with retatrutide