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Optimising thyroid replacement and evidence-based lifestyle interventions should be explored as first-line approaches before considering GLP-1 medications

GLP-1RA (such as exendin-4) treatment can reduce the size of MI impacted cardiac volume in rats, inhibit ventricular dilation, myocardial fibrosis and hypertrophy in vivo [72]

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doi: 10.1210/en.2004-0015

Needle phobia affects an estimated 20-30% of the adult population, and the logistics of cold-chain storage, injection site management, and weekly self-administration limit the reach of these therapies to a fraction of the eligible patient population