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If someone couldnt tolerate 25 mg in the trials, they stayed on a lower dose and tried increasing again later with medical guidance

Patients with higher baseline weights and insulin resistance often see more dramatic results in the first twelve weeks, while those closer to goal weight may progress more slowly

doi:10.1001/jamaophthalmol.2025.3821 38.Weight management injections

Ongoing drug costs with no plan to taper

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Calkin C., McClelland C., Cairns K., Kamintsky L., Friedman A

Some episodes were tied to gastrointestinal problems or the simultaneous use of blood pressure medications