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Expert Opin Pharmacother (2006) 7:2095105

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Development and validation of a new score to assess the risk of posttransplantation diabetes mellitus in kidney transplant recipients

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Acute SSRI use can transiently enhance insulin release, but chronic exposure has been associated with increased risk of IR and weight gain (8, 38)

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These results far exceed what is typically achieved through lifestyle modification alone, where sustained weight loss often falls in the 5 to 10% range even with intensive intervention

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H.PagottoU.et al

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This effect is coupled with a downregulation of dopaminergic tone in mesolimbic structures, including the VTA and NAc, leading to reduced reward sensitivity [13,31]

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