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Expert Opin Pharmacother (2006) 7:2095105
Development and validation of a new score to assess the risk of posttransplantation diabetes mellitus in kidney transplant recipients

Acute SSRI use can transiently enhance insulin release, but chronic exposure has been associated with increased risk of IR and weight gain (8, 38)

These results far exceed what is typically achieved through lifestyle modification alone, where sustained weight loss often falls in the 5 to 10% range even with intensive intervention

H.PagottoU.et al

This effect is coupled with a downregulation of dopaminergic tone in mesolimbic structures, including the VTA and NAc, leading to reduced reward sensitivity [13,31]
