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549 The reactive astrocytes can promote excitotoxic injury of motor neurons by producing nitric oxide and peroxynitrite, which cause mitochondrial damage and apoptosis in cultured neurons, decreasing glutamate transport, releasing pro-apoptotic mediators selectively toxic to motor neurons

Future research should focus on further elucidating the molecular mechanisms linking these conditions and on evaluating targeted interventions to enhance clinical care and quality of life in affected individuals

These CD11c + microglia, characterized by their amoebic shapes along white matter pathways such as the corpus callosum and cerebellum, serve as a primary source of IGF1 and other factors involved in neurogenesis and myelinogenesis, which exert their effects on oligodendrocytes in the newborn brain

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Common Side Effects (reported in clinical trials) Nausea the most common side effect, especially when your dose goes up