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While Mounjaro is not directly known to cause NAION, its effects on blood sugar and potential impacts on vascular health in diabetic patients could theoretically contribute to an increased risk

Disturbance of insulin signaling in diabetic patients might lead to the abnormal expression of Syn, damage to mitochondrial function, increase in mitochondrial oxidative stress, and down-regulation of the PI3K/AKT pathway, which in turn could promote the occurrence and development of PD (62)

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