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EMBO Rep (2006) 7(9):8805.10.1038/sj.embor.7400779 117 BertolottiAWangXNovoaIJungreisRSchlessingerKChoJHet alIncreased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice

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Particularly in patients who are younger, who are in earlier stages of facial aging, or who are not yet ready for more invasive surgical procedures, strategies like hyaluronic acid [HA] fillers and autologous fat transfer can provide subtle and satisfying improvements, he said

Although preclinical models frequently employ dosing regimens that limit direct translational applicability, they remain essential for delineating pharmacodynamic mechanisms, including those underlying the well-established CV benefits of GLP-1 RAs, which could also have implications for ED [191]

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