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Their tendency to cause weight loss is thrusting them into a significant role in the management of obesity

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Most of the research was done in animals or in a laboratory

These FDA-approved medications are widely recognized for their effectiveness in weight management and the treatment of type 2 diabetes

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To prospectively test the ability of this model to design new peptides with specific activity, we used a simple optimization strategy to design 15 peptides, five in each of three different activity profiles: selective potency at GCGR, selective potency at GLP-1R or high-potency at both receptors