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The BBC notes that in 2023, British Columbia placed restrictions on Americans purchasing its Ozempic after finding 15% of prescriptions for the drug came from the United States, mostly through Canada-based online pharmacies [Source: bbc.com/news/articles/c142y4p2eyxo]

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Yan Y, Liu B, Du J et al (2021) SGLT2i versus ARNI in heart failure with reduced ejection fraction: a systematic review and meta-analysis

This positions amycretin as a direct competitor to retatrutide, likely reaching market around the same time
The cagrilintide side effect profile and the cagrilintide weight loss data suggest this amylin analog could offer a complementary or alternative approach to GLP-1 therapy