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12,13 Modifications to prolong the half-life of GLP-1 RAs include sequence substitutions conferring resistance to DPP-4, along with acylation (liraglutide and semaglutide), covalent bonding to modified Ig fragment crystallisable domain (dulaglutide), or covalent bonding to albumin

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[DOI] [PMC free article] [PubMed] [Google Scholar] 162.Sarin H.V., Lee J.H., Jauhiainen M., Joensuu A., Borodulin K., Mnnist S., Jin Z., Terwilliger J.D., Isola V., Ahtiainen J.P., et al

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