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Previous studies have indicated that the GLP-1 signaling pathway is involved in regulating c-Fos expression and promoting neuronal proliferation [22,33,53], and its enhanced transmission leads to an increase in anxiety-like behaviors [26,46], while the expression of c-Fos in related brain regions is elevated [45,68,69]
Previous research has looked at single substances such as alcohol and cannabis, but a 2026 observational study in the British Medical Journal looked at multiple substances and extended its reach into opioids
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[DOI] [PubMed] [Google Scholar] 74.Guan H.-P., Yang X., Lu K., Wang S.-P., Castro-Perez J.M., Previs S., Wright M., Shah V., Herath K., Xie D., et al
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