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doi: 10.3945/ajcn.111.024927

For example, Smits et al

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Chronic Ex-4 treatment To test whether chronic icv administration of Ex-4 alters autonomic nervous system activity, we administered icv Ex-4 (10 ng/h) continuously during a 28 day period

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Researchers combined results from large, randomized, placebo-controlled trials designed to track long-term heart outcomes in these groups