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11.8 per 100 person-years, p = 0.34)

5 In 2016, the American Diabetes Association treatment guidelines added a new section on obesity management and recommended GLP-1 RAs for their weight loss benefits

When Semaglutide (W) (2.4 mg) was combined with dietary and exercise modifications, patients without diabetes who had a BMI of at least 30 or a BMI of at least 27 with a weight-related condition lost an average of 15% of their body weight (as opposed to 2.4% when diet and exercise were implemented alone)

In the mentioned semaglutide dosing study, adverse events (side effects) occurred in 43.5% of placebo recipients (the so-called nocebo effect wherein people taking placebo still report side effects)

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Hypernatremia ( SIADH SIADH Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a disorder of impaired water excretion due to the inability to suppress the secretion of antidiuretic hormone (ADH)