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To make the symptom more tolerable, consider the following strategies from Nancy Oliveira, a registered dietitian and manager of the Nutrition and Wellness Service at Harvard-affiliated Brigham and Women's Hospital

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While evidence for resurrecting compromised vascular plumbing remains mixed and awaits larger trials, GLP-1s rescue the brain-testicular feedback loop from the grip of adipose tissue

Such suboptimal receptor exposure might be especially deleterious for the central effects of GIP on food intake, given that higher doses of GLP-1 are also required to decrease body weight and food intake relative to improving glycemia