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GLP-1 receptor agonists like semaglutide and tirzepatide act on multiple brain regions beyond appetite control

Tichansky DS, Boughter JD, Madan AK

Figure 2 Exenatide, a peptide of 39 amino acids, has a much slower metabolism than endogenous GLP-1 (half-life of 3-4 h) (119, 120)

35: e14523

*Duration of diabetes was based on time since diagnosis

Obesity Reviews, 22(12), e13313
