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Fatigue is reported by some patients using GLP-1 medications, but it's often temporary and manageable

Agents that agonize glucagon-like peptide 1 receptors, including those that co-agonize other anorexigenic hormone receptors, lead to substantial weight loss and benefits in people with varying obesity-related complications, with further trials underway

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Start with a standard-dose PPI taken 30-60 minutes before a meal once daily, and escalate to twice-daily dosing if symptoms persist after 4-8 weeks