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However, patients may still experience side effects such as nausea, diarrhea, or electrolyte imbalances, which should be carefully monitored

The mechanism of action involves several physiological effects: GLP-1 receptor agonists stimulate insulin secretion in a glucose-dependent manner, suppress glucagon release, slow gastric emptying, and reduce appetite through central nervous system pathways

Holst has served as a consultant or advisor to Novartis Pharmaceuticals, Novo Nordisk, Merck Sharp & Dohme, and Roche and has received fees for lectures from Novo Nordisk, Merck Sharp & Dohme, and GlaxoSmithKline

Labeling update (2026): The FDA recently removed suicidal behavior and ideation language from the labeling of certain GLP-1 medicines used for chronic weight management, following a comprehensive safety review that found no evidence of increased risk

Epicardial adipose tissue GLP-1 receptor is associated with genes involved in fatty acid oxidation and white-to-brown fat differentiation: a target to modulate cardiovascular risk

According to multiple clinical trials, these medications can help individuals lose 15% or more of their body weight over time