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Short-acting GLP-1 RAs, exenatide and lixisenatide, are associated with a transient (112 h) mean placebo- and baseline-adjusted 24-h HR increase of 13 beats per minute (bpm)

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These results suggest chronic treatment with GLP-1R agonists could lead to proliferation/chronic activation of PSCs, which may lead to important effects in the pancreas.

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