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While specific renal dose adjustments are not routinely required for GLP-1 receptor agonists or tirzepatide, patients should be monitored for dehydration and potential kidney injury, particularly when starting treatment

The cost of tirzepatide injections can be a significant factor for patients considering this weight loss option

Over-dilution wastes valuable peptide and makes precise dosing difficult

doi: 10.1038/nrendo.2015.51 51 MllerTDBlherMTschpMHDiMarchiRD

However, the extent to which high dosage of sibutramine can modify the gut microbiota and impact liver and gut health in both obese and non-obese individuals remains insufficiently investigated 16

Research in humans is still scarce