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When that signaling pathway gets disrupted by months or years of chronic stress, cortisol production doesn't just drop

TrumpRx, a federal purchasing portal announced November 2025 and launching January 2026, uses the threat of 100% tariffs on pharmaceutical imports to force Novo Nordisk, Eli Lilly, and other manufacturers into Most Favored Nation pricing agreements that bring GLP-1 injectables down to ~$350/month for cash-pay users, bypassing the insurance, PBM, and traditional pharmacies & competing directly with Ro by redirecting patients who search for drugs on TrumpRx.gov to the same manufacturer cash-pay pharmacies Ro pipes into

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Weight loss, in turn, can significantly reduce the load on knee joints, alleviating pain and improving mobility

Exit often gets monetized

As discussed by Tuccinardi et al., AOMs targeting adiposity and CV risk offer a novel treatment paradigm, mirroring recent T2D strategies [9] (Figs