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They are called surrogate markers

but it's more accessible, it's easier to fit into your daily routine." Lilly licensed the molecule, orforglipron, from Japanese drugmaker Chugai in 2018, paying just $50 million up front for global rights to the drug

Among the reported findings after 12 weeks: BMI: 27.13 vs 28.49 Waist circumference: 88.32 cm vs 92.21 cm Fasting plasma glucose: 6.59 vs 7.68 mmol/L 2-hour postprandial glucose: 8.24 vs 10.13 mmol/L HbA1c: 6.69% vs 7.13% HOMA-: 50.03 vs 31.26 The paper also reported greater reductions in total cholesterol and triglycerides in the dorzagliatin combination arm, while adverse event rates were similar between the two groups

UK consensus and NICE resources emphasise these mechanisms and management approaches
23% are somewhat likely to start covering them, while only 3% are very likely to do so
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