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Last reviewed: June 18, 2026 Last updated: June 18, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Hypoglycemia is observed when GLP-1 receptor agonists are combined with insulin therapy, so clinicians and patients have to be attentive to reducing insulin dosages given the weight loss induced by GLP-1 receptor agonists

Individuals who are pregnant, planning on becoming pregnant, breastfeeding, have a history of severe kidney or liver disease, pancreatitis, gallbladder disease, diabetic retinopathy, thyroid C-cell tumors, certain types of cancer, or those who have had severe hypersensitivity to Semaglutide or any of its components may not be suitable for this treatment

The Balanced Truth: These medications are helping millionsbut theyre not right for everyone

What social determinants of health, if any, might impact this patients ability to initiate and sustain therapy