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The glucagon receptor component is expected to provide unique metabolic effects including increased energy expenditure and enhanced hepatic lipid oxidation, which may contribute to the substantial body weight reductions observed in Phase 2 clinical trials

In 2023, the STEP-HFpEF trial showed that semaglutide, a once-weekly long-acting GLP-1 RAs, significantly improved exercise capacity, enhanced quality of life, and notably reduced body weight while mitigating inflammation over 52 weeks in obese patients with HFpEF compared to placebo [9]

If food makers respond, they can support healthier choices

A 2022 human study published in Nutrients reported higher post-meal GLP-1 after green tea catechins (3)

Did you know that nearly 700,000 cholecystectomies are done every year in the United States

Retatrutide Phase 2 data showed remarkable improvements in metabolic associated steatotic liver disease, previously called NAFLD