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GLP-1R-immunolabeling was also robust in dendrites and axons, especially in laminae IIIII in the dorsal horn

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This shift from "Large Molecule/Biologic" to "Small Molecule/Chemical" changes everything: Easier Synthesis: They are produced via standard chemical synthesis rather than complex biological fermentation or solid-phase peptide synthesis (SPPS)

Large analysis finds no significant link between GLP-1 receptor agonist exposure and major birth defects, though urinary malformation risk needs further study.

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