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Oral formulations have a shorter half-life.[ref] In clinical trials, GLP-1 RAs improved lipid profiles, increased satiety, slowed gastric emptying, reduced inflammation, and had neuroprotective effects.[ref] The slowing of gastric emptying and reducing inflammation may play a role in weight loss, along with the decrease in appetite and eating less

Empagliflozin in Heart Failure: Notably, empagliflozin has demonstrated efficacy in treating heart failure, including in patients with a preserved ejection fractiona condition where the heart muscle contracts normally but the ventricles do not fill with enough blood

However, retatrutide lacks the long-term safety data that tirzepatide has accumulated, and it is not yet FDA-approved for any indication

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Those signals are clinically significant, but retatrutide remains investigational and is not a routine prescription option outside clinical trials