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This primarily appears to be due to clinical results since GLP-1s lower A1C, reduce weight, improve cardiovascular outcomes, and potentially many other benefits
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The potent GLP-1 receptor antagonist, exendin-[939] (Ex9), blunted improvements in glucose tolerance in linagliptin-treated control mice and in GcgRAPDX1Cre mice

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Accessed October 30, 2025