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While both hormones aid in insulin secretion, GLP-1 has a broader range of actions, including appetite suppression and slowing gastric emptying, which are particularly beneficial for weight loss

Huang, M

Weight-Loss Results in Clinical Trials Clinical trials suggest retatrutide may lead to greater average weight loss than earlier medications, though direct head-to-head studies are limited

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Additionally, angiotensin II contributes to endothelial dysfunction by inducing expression of vascular endothelial growth factor and increasing reactive oxygen species, which reduce the bioavailability of vasodilators (such as nitrous oxide) responsible for maintaining normal glomerular vascular tone [14]

The change in triglycerides after treatment was greater in the FPLD group compared with the DM group ( P = 0.02)