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For patients with no pre-existing SUD, GLP-1 use was associated with a 14% lower overall risk of developing any new substance use disorder

In a review of animal and human tissue and cellular studies, Nauck identified 13 cellular processes that lead to the formation and rupture of atherosclerotic plaques, all of which GLP-1s can slow down or stop

[16] [19] Some research suggests these anti-inflammatory effects may occur alongside weight loss, though the relative contributions of direct immunomodulation versus metabolic improvement remain unclear

Preclinical and translational studies provide plausible explanations for these observed cardiovascular effects

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