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Additionally, the serine protease dipeptidyl peptidase 4 (DPP4) limits the bioavailability of GIP, GLP-1, and GLP-2 by cleaving the first two amino acids, rendering them inactive (Deacon et al., 1995a

This matters for fat loss because chronic inflammation is now understood to be a driver of insulin resistance, which in turn makes losing body fat significantly harder

American Diabetes Association: Medications for Type 2 Diabetes Obesity Action Coalition: Lifestyle Habits to Treat Obesity Centers for Disease Control and Prevention: About Insulin Resistance Sandy Bassin, MD Medical Reviewer Sandy Bassin, MD, is an endocrinology fellow at Mount Sinai in New York City

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Therefore, in patients with significantly impaired renal function or in infants, the therapy should be used only if clearly indicated and with careful monitoring