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Discussion Key Study Findings The findings from the NMA support the clinical effectiveness and safety of tirzepatide compared with semaglutide and liraglutide, for multiple clinical outcomes considered in the management of obesity and overweight in patients without T2D, including weight reduction and cardiometabolic risk factors, such as waist circumference, lipids, blood pressure and glycaemic parameters

Activation of Piezo1 leads to calcium influx and subsequent activation of the CaMKK/CaMKIV-mTORC1 signaling pathway, promoting GLP-1 production [11]

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We used the HepG2 cell line treated with oleic acid as a steatosis model and confirmed that Ex-4 significantly reduces OA-induced lipid accumulation

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The study not only met its primary end point but really had remarkably impressive results